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KMID : 0861020200350060055
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Korea Journal of Herbology
2020 Volume.35 No. 6 p.55 ~ p.68
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Analgesic Effect of Blue Honeysuckle on the Rat Menopausal Pain, Primary Dysmenorrhea
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Joo Si-Chan
Lee Sang-Nam
Choi Seong-Hun
Park Ji-Ha
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Abstract
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Objectives : We observed the possibilities that blue honeysuckle has favorable analgesic or refinement effects on the Primary dysmenorrhea (PD) in rats.
Methods : Estradiol benzoate and oxytocin were used to induce the PD rat model. And Blue honeysuckle concentration lyophilized powders (BH) 500, 250 and 125 ㎎/㎏ and 500 ㎎/㎏ of Lonicerae Flos aqueous extract lyophilized powders (LF) were orally administered, once a day for 10 days at 30 min after each estradiol benzoate treatment. Then the changes on the body weights and gains during experimental periods, abdominal writhing response for analgesic activities, uterine weights, uterus lipid peroxidation, antioxidant defense system - glutathione contents, superoxide dismutase and catalase activities, NF-κB and COX-2 mRNA expressions were monitored with uterus histopathology including immunohistochemistry for tumor necrosis factor (TNF)-α and inducible nitric oxide synthase (iNOS)..
Results : Inflammatory and oxidative stress mediated PD signs were favorably and dose-dependently inhibited by 10 days continuous oral administration of three different dosages of BH - 500, 250 and 125 ㎎/㎏ as comparable to those of indomethacin(IND) 5 ㎎/㎏ treated rats in BH 500 ㎎/㎏ administered PD rats, and similar to those of LF 500 ㎎/㎏ in BH 125 ㎎/㎏, at least in a condition of the present PD rat model.
Conclusions : The results suggest that BH has favorable analgesic and refinement activities on the estradiol benzoate and oxytocin treatment-induced PD signs through anti-inflammatory and antioxidative potentials.
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KEYWORD
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Primary dysmenorrhea, dysmenorrhea, Blue honeysuckle
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